Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates—only 10% after five years. One of the factors contributing to its aggressiveness is its tumor microenvironment, known as the stroma, which makes up the majority of the tumor mass and consists of a network of proteins and different non-tumor cells. Among these, fibroblasts play a key role, helping tumor cells to grow and increasing their resistance to drugs.