High IL-8 levels in gingival crevicular fluid and total oral fluid predict the responsiveness of steps 1 and 2 of Orthodontic therapy suggests a study published in the Journal of Clinical Periodontology.A study was done to investigate the association between interleukin-8 (IL-8) levels in gingival crevicular fluid (GCF) and total oral fluid (TOF) and the responsiveness to steps 1 and 2 of periodontal therapy. One-hundred and fifty-nine patients affected by periodontitis received steps 1 and 2 of periodontal therapy. At baseline, TOF and GCF samples were collected and analysed for IL-8 (Il-8TOF/IL-8GCF) using flow cytometry. Therapy outcomes were relative proportions of residual periodontal pockets (PPD%), pocket closure (PC) rates and pocket probing depth (PPD) reductions; these were associated with IL-8TOF/IL-8GCF. ResultsHigh IL-8TOF was significantly associated with higher residual PPD% (p = 0.044) and lower: PPD reduction compared to low IL-8TOF (high 0.79 ± 1.20 mm vs. low 1.20 ± 1.20 mm, p < 0.001) in non-smokers, while in smokers high IL-8GCF was related to lower PPD reduction (high 0.62 ± 1.22 mm vs. low 0.84 ± 1.12 mm, p = 0.009). Furthermore, high baseline IL-8TOF was significantly associated with poorer PC rates compared to medium and low concentrations in both non-smokers (high 41% vs. medium 55% vs. low 58%, p < 0.001) and smokers (high 34% vs. medium 44% vs. low 46%, p < 0.001). High IL-8 concentrations at baseline had a significant impact on residual PPD%, PC rates and PPD reduction. The findings suggest that, especially in non-smokers, baseline IL-8 levels collected from the TOF could serve as a component in the estimation of responsiveness to steps 1 and 2 of periodontal therapy.Reference:Bumm, C., Schwendicke, F., Heck, K., Frasheri, I., Summer, B., Ern, C., Heym, R., Werner, N. and Folwaczny, M. (2024), The Role of Interleukin-8 in the Estimation of Responsiveness to Steps 1 and 2 of Periodontal Therapy. J Clin Periodontol. https://doi.org/10.1111/jcpe.14055Keywords:High, IL-8 levels, gingival, crevicular fluid, total, oral fluid, predict, responsiveness, steps 1, Orthodontic, therapy, Study, Bumm, C., Schwendicke, F., Heck, K., Frasheri, I., Summer, B., Ern, C., Heym, R., Werner, N. and Folwaczny, M, Journal of Clinical Periodontology